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Glass Bridge Merges Ancient Wisdom With Cutting-Edge Design
Posted by Okachinepa on 03/07/2025 @ 
SynEVOL Source
Building bridges: A feat of engineering and artistry
Courtesy of SynEvol
Credit: University of Pennsylvania


Bridges are an essential aspect of everyday life in Philadelphia, where there are over 500 of them. Bridges allow people to connect with one another in a city that is characterized by its waterways.

Architect and structural engineer Masoud Akbarzadeh has pushed the challenge a step further by building a bridge out of glass, a material that is often thought to be inappropriate for a bridge at all. Traditional bridges connect two sides of a chasm.

A stunning 30-foot-long edifice made entirely of interlocking hollow glass components is the end product. Upon initial observation, the bridge seems incredibly delicate, a shimmering expanse of translucent polygons.

According to Akbarzadeh, an associate professor of architecture at the Weitzman School of Design, "bridges are more than just structures spanning rivers and chasms; they symbolize physical and metaphorical connections."

"They represent the human attempt to bridge gaps and bring dissimilar worlds together as routes between two locations. Beyond their usefulness, however, bridges are powerful representations of cooperation, understanding, and togetherness.

By using glass's strength in a compression-dominant structural form, the Glass Bridge does away with the requirement for conventional reinforcements like steel.

"All these pieces alone, hollow glass units, might seem quite brittle—and they are," says Akbarzadeh, "but depending on how you design to put these glass units together, they start relying on each other, and the units' assembly establishes a path for the load to be transferred efficiently. Thus, the bridge gains strength as a whole."

Akbarzadeh compares this idea of the components creating a stronger whole to human society, pointing out that "for a better-functioning society, we need to rely on each other. We need to trust each other, and together, only with transparency, we can work and unite to create an advancing world that serves the people in it."

Over three weeks in 2024, he and his team constructed the bridge. As a research assistant in Akbarzadeh's Polyhedral Structures Laboratory, Boyu Xiao, a 2024 Weitzman Master of Architecture graduate, said, "the process was a test of both engineering ingenuity and sheer physical endurance."

Formally titled "Glass Bridge: The Penn Monument for Hope," the bridge is a tall structure that will be on exhibit at the Corning Museum of Glass until September 1. For a forthcoming documentary, Greenhouse Media spoke with team members and photographed the fabrication process before to its introduction at the Museum.

Its path to completion, however, was far from straightforward. The designs were prepared after six years of planning, drafting, editing, and negotiating with international vendors. And in only twenty-one demanding days in November, a rotating group of engineers, architects, fabricators, and researchers came together in Corning, New York, each of whom was instrumental in making the project a reality.

A year into his time at Penn, in the summer of 2017, Akbarzadeh started working on the preliminary design and conceptualization of the Glass Bridge.

"At the beginning, it was just an idea about using thin sheets of glass to build a super-efficient structure," Akbarzadeh recalls. "But it very quickly grew into a larger study of structural resilience."


Building bridges: A feat of engineering and artistry
Courtesy of SynEvol
Credit: University of Pennsylvania


According to him, the bridge and its prototype are based on engineering and architectural ideas that date back thousands of years, especially those related to funicular design, which is the practice of creating buildings that naturally flow with the forces that act through them, mainly using compression to generate strength and stability.

As early as 4000 BCE, the Mesopotamians used these concepts to build arches and domes. Later, the Romans used them to build aqueducts, bridges, and imposing buildings like the Basilica of Maxentius, which used arches and vaults to balance stresses.

The basic mechanics, however, were not formally established until the 17th century, despite the fact that ancient builders relied on empirical perception. In 1675, English mathematician and physicist Robert Hooke developed a fundamental idea in structural design: "As hangs the flexible line, so but inverted will stand the rigid arch."

Despite its exquisite simplicity, Hooke's study disclosed a deep truth: under uniform load, an inverted hanging chain naturally follows the ideal compression curve of an arch.

"If you have the right form," Akbarzadeh clarifies, "you can reduce the material and work with efficient and elegant forms."

William John Macquorn Rankine and James Clerk Maxwell, two of Akbarzadeh's main mentors, drew inspiration from Hooke's ideas. He claims that these engineers from the 19th century "formalized the mathematical foundations of graphical statics, providing methods for visualizing and analyzing the internal forces within structures."

Since his Ph.D. thesis in 2012, Akbarzadeh has been at Penn since 2017, refining Rankine's 1864 proposal by extending the methodology of graphic statics from two dimensions to three. He described this in his new book, "Polyhedral Graphic Statics."

The geometry of the bridge was created by Akbarzadeh and his group to channel forces along optimal compression pathways. In order for the bridge's arch to support the weight largely through compression rather than bending forces, every glass unit, joint, and angle was adjusted. This technique dates back to the Sumerian U arches and is today made possible by state-of-the-art computer and fabrication methods.

Beyond drawings, calculations, and simulations, a small but essential roughly 10-foot prototype was the first step in bringing their idea to life. This model, a tangible representation of the team's digital work, served as a crucial testing ground.

"Every flaw, every misalignment, and every unexpected failure was logged, studied, and resolved in preparation for a full-scale bridge to come," says Yao Lu, a key member of the design team and a 2024 Ph.D. graduate of the architecture program at the Weitzman School who is currently an assistant professor of architecture at Thomas Jefferson University.

When Lu created the prototype, he was only beginning his doctoral studies at Penn. According to him, one of the first challenges was figuring out how to join the glass modules without creating stress points that could cause fractures. It was constructed using the same fundamental elements intended for the finished bridge: modular hollow glass units interlocked by precisely engineered acrylic connectors.

Male-and-female key joints, which are interlocking geometries that would physically stop the modules from falling apart, were the team's first trial, but "the male and the female shapes were really, really difficult to make out of glass," according to Lu.


Building bridges: A feat of engineering and artistry
Courtesy of SynEvol
Credit: University of Pennsylvania


The majority of glass materials are two-dimensional, or planar. Instead of producing the required precision, the team's attempts to use heat and formwork to mold the glass into a three-dimensional structure introduced new structural problems.

The little module was eventually put together using structural double-sided tape, according to Akbarzadeh. The device was then shipped 12 miles west to Villanova University, where it was tested under stress conditions and withstand up to 41.6 kilopounds of compression.

"The test data was just super exciting because it showed us that this humble, cheap material could have a lot of load-bearing capacity," Lu explains.

The team decided to use structural VHB tape, an industrial adhesive renowned for its strength and flexibility, to fix flat panes of glass fused with precisely cut acrylic connectors for their prototype.

"This approach permitted the necessary tolerance and ease of assembly without compromising the integrity of the glass," explains Lu.

"The team over at Villanova worked to identify an interface material that could prevent catastrophic glass-on-glass contact between adjacent modules during assembly and under increased load."

Polyvinyl butyral (PVB), a laminate substance often used in safety glass, served as a buffer between the glass modules after their testing. By providing the ideal ratio of rigidity to flexibility, PVB prevented localized stress concentrations and allowed the forces inside the bridge to disperse uniformly.

"But with these connectors, every cut, every angle, every dimension had to be accurate within 0.1 millimeters," says Akbarzadeh.

"Even the slightest misalignment can spread throughout the whole span when working with 124 distinct glass parts. The entire edifice might have collapsed under its own weight if we hadn't maintained that degree of accuracy."

The team worked with a number of Chinese and German companies to attain this level of accuracy. Another level of complexity was created by the logistics of putting the bridge together in Corning. Given the delicate nature of the materials and the thousands of miles each component traveled to reach the United States, it was imperative that every hollow glass item arrive on site undamaged and intact.

When Xiao says, "Shipping was one of our biggest nightmares," "We had to make sure that everything arrived on schedule, that customs clearances went without a hitch, and that the glass wasn't broken during transit. Our building timeline may have been in danger from even a minor delay. This is precisely what took place.

Following Lu's graduation, Xiao assumed responsibility for the project's daily operations and served as its logistical hub, managing everything from team scheduling to partial shipments. "We didn't just have to build a bridge," he says. We had to come up with a plan for constructing a bridge that had never been done before.

The team encountered a logistical obstacle as soon as the bridge's components arrived in Corning in early November. The glass modules were delayed by two weeks because the shipping business had deprioritized their freight. But the exhibit's opening date was set in stone. As a result, the crew had a few days, not weeks, to arrange everything.

"I was there from November 12th to the 15th for the first phase, where we installed the metal supports and wooden formwork that would support the bridge during construction," explains Xiao. "That was only setting the foundation. The arrival of the entire crew on November 21st was the big push.

It was all hands on deck after that, according to Akbarzadeh. He joined the team from the Polyhedral Structures Laboratory, as did Amir Motevaselian, a recently hired research assistant who had been put into the thick of things.

According to Lu, the glass bridge required an almost unimaginable level of precision, in contrast to a normal bridge building, where materials like steel and concrete allow for some margin of error. The margin for mistake was only 0.1 millimeters, which is hardly noticeable to the naked eye, and each hollow glass unit had to match precisely with its neighbors.

"The museum staff were nervous about us taking up so much space, coming in with large tools," Xiao says. "Everything around us seemed so delicate since it's a museum of glass. It appeared to be anarchy as we were sweating, moving heavy equipment, slicing plastics, and hauling these enormous crates.

The crew had meticulously planned each stage of the assembly process by the time the final shipment reached Corning. During construction, the structural supports that braced the arch had already been put in place. In order to stabilize the bridge until the last keystone glass modules could be secured into position and the structure could bear its own weight, a temporary timber formwork was created.

Nevertheless, the gathering would put everyone's mental and physical fortitude to the test.

"We had days where we worked from sunrise until the museum closed, lifting heavy glass units by hand, triple-checking measurements, and holding our breath during every installation," Xiao writes. Each item has to be manually lifted and positioned. There were times when it seemed like we were constructing this monstrosity with our bare hands, even though the museum staff assisted with the larger sections.

They once had to carefully disassemble and realign a number of pieces due to a misalignment in the arch caused by an incorrectly calibrated support. At another, the bridge could not be adequately supported during assembly due to an incorrect positioning of the wooden formwork.

"The worst part was that the whole structure had to be self-supporting by the end," adds Xiao. "It's an arch—until you put in the last keystone piece, the whole thing is unstable."

The last several days of building were quite stressful. The final few components had to be positioned precisely because any mistake would jeopardize the span's structural stability. However, the team as a whole exhaled in relief as the keystone unit came into alignment.

The bridge stood tall on November 30th, following a week of grueling days and late nights.

A glittering arch of glass, delicate in appearance yet sturdy in structure, is the tangible result of months of planning, manufacture, and logistical coordination. It is a tribute to the harmony of human cooperation, engineering precision, and aesthetic beauty.

"This bridge shows that we can rethink materials, that we can push the boundaries of engineering, and that we can build in ways that are both efficient and elegant," Akbarzadeh stated.

After months of balancing logistics, material limitations, and restless nights, Xiao's response was more concise.

"We did it," he declares. "Against all odds, we actually did it."

Reducing the Weight of Augmented Reality Eyewear
Posted by Okachinepa on 03/07/2025 @ 
SynEVOL Source
Lightening the load of augmented reality glasses
Courtesy of SynEvol
Credit: University of Tokyo 


To overcome some of the current drawbacks of augmented reality glasses, namely their bulk and weight, a global team of scientists created technology that allows them to receive visuals projected from a projector. 


With well-known gaming apps like Pokémon Go and real-world applications in industries like education, manufacturing, retail, and healthcare, augmented reality (AR) technology—which superimposes digital data and virtual objects on an image of the real world seen through a device's viewfinder or electronic display—has become more and more popular in recent years. However, because wearable AR devices are heavy and require technical components and batteries, their acceptance has been slow over time.

By incorporating virtual features, AR glasses in particular have the ability to change a user's physical surroundings. Even with numerous major technological advancements over the years, AR glasses are still cumbersome, unwieldy, and lack the processing speed, battery life, and brightness necessary for the best possible user experience.

A group of researchers from the University of Tokyo and their partners created AR glasses that don't create images; rather, they receive them from beaming projectors in order to get around these restrictions.

"This research aims to develop a thin and lightweight optical system for AR glasses using the 'beaming display' approach," stated Yuta Itoh, the first author of the research paper and project associate professor at the University of Tokyo's Interfaculty Initiative in Information Studies.

"This method enables AR glasses to receive projected images from the environment, eliminating the need for onboard power sources and reducing weight while maintaining high-quality visuals."




Lightening the load of augmented reality glasses
Courtesy of SynEvol
Credit: University of Tokyo 


Before the research team's design, the practicality of light-receiving AR glasses using the beaming display approach was severely limited by the angle at which the glasses could receive light. Light-receiving AR glasses with cameras that were angled only five degrees away from the light source could display clear images.

By adding a diffractive waveguide, or patterned grooves, to regulate the direction of light in their light-receiving AR glasses, the researchers were able to get around this restriction.

"By adopting diffractive optical waveguides, our beaming display system significantly expands the head orientation capacity from five degrees to approximately 20–30 degrees," Itoh stated.

"This advancement enhances the usability of beaming AR glasses, allowing users to freely move their heads while maintaining a stable AR experience."


Lightening the load of augmented reality glasses
Courtesy of SynEvol
Credit: University of Tokyo 


In particular, screen and waveguide optics make up the two parts of the team's AR glasses' light-receiving system.

First, a diffuser receives the projected light and evenly distributes it toward a lens that is focused on waveguides in the material of the glasses. The image light is directed toward gratings on the eye surface of the glasses after first striking a diffractive waveguide. In order to produce an augmented reality image, these gratings are in charge of capturing image light and guiding it toward the user's eyes.

To test their approach, the researchers built a prototype that used a laser-scanning projector angled between zero and forty degrees from the projector to display a 7-millimeter image onto the receiving glasses from a distance of 1.5 meters.

Crucially, the team's AR glasses can now receive projected light with acceptable image quality from an angle of around five degrees to about twenty to thirty degrees thanks to the addition of gratings, which focus light both within and outside the device, as waveguides.

The team admits that further testing and improvements are necessary, even though this new light-receiving technology increases the usefulness of light-receiving AR glasses.

"Future research will focus on improving the wearability and integrating head-tracking functionalities to further enhance the practicality of next-generation beaming displays," Itoh stated.

To further improve their usefulness in a three-dimensional setting, future testing configurations could ideally track the location of the light-receiving AR glasses and use steerable projectors to move and beam images to them appropriately. To enhance image quality, one can also employ various light sources with higher resolution.

Ghost pictures, a narrow range of view, monochromatic images, flat waveguides that cannot accept prescription glasses, and two-dimensional images are some of the drawbacks of the team's present design that they also seek to overcome.

Using the One-Pot Process Produces Inorganic and Polymer Battery Electrolytes
Posted by Okachinepa on 03/07/2025 @ 
SynEVOL Source
New "one-pot" technique a breakthrough for material synthesis
Courtesy of SynEvol
Credit: UChicago Pritzker School of Molecular Engineering



The process of making battery electrolytes, which transport the charged particles between the two terminals of a battery, has always involved trade-offs. 

Solid- state inorganic electrolytes are very effective in the moving particles, but because they are inorganic and solid, they are also brittle, challenging to deal with and challenging to connect to the terminals smoothly. Although polymer electrolytes are a pleasure to deal with, they just aren't as effective at moving the charged ions. 

The outcomes of combining the two to make hybrid electrolytes are well mixed.  "A problem exists. Asst. Prof. Chibueze Amanchukwu of the University of Chicago Pritzker School of Molecular Engineering (UChicago PME) asked, "is a hybrid the best of both worlds in terms of higher ionic conductivity from the inorganic and good mechanical properties from the polymer, or is it a combination of their worst properties?"

Amanchukwu Lab has developed a unique method that simultaneously creates inorganic and polymer electrolytes in the same vessel.  This "one-pot" in-situ technique combines the flexibility of the polymers with the conductivity of the Inorganic particles to produce a regulated, uniform blend. 

"When you make lithium metal batteries, the in-situ method outperforms the physical mixing method quite substantially," Amanchukwu stated. 

The new method will affect semiconductor research, electronics, industrial coatings, sealants, and any other sector that depends on hybrid materials, even though the work was centered on battery electrolytes. 

Let's imagine you're looking for anything that can bend and stretch, such as wearable technology.  According to Priyadarshini Mirmira, the first author, "you could engineer the polymer so that you have mechanical flexibility with that material."

Currently, two streams of synthesis are used to create hybrid materials. Even if both are synthesizing simultaneously, the inorganic polymer ingredients are created independently, and mixing the two materials takes more time. 

Although it is a pain in the lab, it's a financial barrier at the large production sizes needed by the industry. 

"From an industrial standpoint, that's really difficult and expensive to try to scale up, "Mirmira stated."If you can make the two of them in a one-pot approach, you've now reduced the labor that you need in order to make the hybrid material."

The same issues that arise when high-tech synthetic materials are mixed together also arise when oatmeal is mixed--lumps. Ineffective batteries, clumped sealants, and less functional electronics are the results of a clotted, lumpy combination. 

"Let me combine the powder, ceramic, and polymer that I have prepared," Amanchukwu stated. "What constitutes a decent combination is the problem. Do you want to blend well? Don't you? Do the particles group together? Do they not?

The team observed some elements coming together chemically in addition to creating the ideal physical blend by combining the ingredients in a single pot. 

"For some combinations of the inorganic precursor and the polymer precursor, we saw evidence of cross-linking, meaning a chemical bond between the inorganic and the polymer," Amachukwu stated. "That's just new materials chemistry that got us excited."

Since lithium batteries are the most widely utilized in EVs, grid storage, and other uses, the paper concentrated on them. However, the method can also be applied to sodium batteries, which are becoming a more affordable and accessible substitute for lithium batteries.

"It's really a matter of changing one of the reactants on the inorganic to make it applicable to a sodium battery cell as well," Mirmira added.

"A couple of different knobs to tune," Mirmira added, will be necessary to scale the one-pot method up to the levels required for industrial manufacture. First and foremost, the procedure needs to be carried out entirely without air and using argon or another inert gas. Compared to a factory floor, that is simpler to maintain in a lab.

The pot then heats up. It will take careful tweaking to reach industrial levels; the vessel must heat up enough to manufacture the polymer without exceeding the temperature at which the components degrade.

"When you scale up this reaction, you're going to have more material, the vessel is going to get even more hot, essentially," Mirmira stated. "So you've got to worry about temperature control."

The research will result in flawless, homogenous hybrids produced in a way that is both affordable and chemically efficient after those challenges are resolved.

"That kind of control of being able to have a fully integrated inorganic polymer material was a challenge we were trying to solve, and a pretty cool thing we were able to achieve," Mirmira stated.




Engineers Break Down Batteries From Chinas Leading Ev Makers and Tesla
Posted by Okachinepa on 03/07/2025 @ 
SynEVOL Source

Engineers took apart batteries from Tesla and China's leading EV manufacturer to see what's inside
Courtesy of SynEvol 
Credit: Jonas Gorsch



The electric vehicle (EV) market is dominated by two main manufactures, BYD, which dominates the Chinese EV market, and Tesla, which is most well-known in North America and Europe. The technical makeup and properties of these battery cells are still unknown, though, as neither company has disclosed much information about their batteries. A group of researchers disassembled one of each manufacturer's in order to compare them and gain a better understanding of how EV batteries work in general. 

The results shows that although BYD's batteries place more emphasis on volume efficiency and less costly materials.  Tesla's batteries prioritize high energy density and performance. The study found that BYD's battery is more efficient overall because it makes heat control simpler. 

"There is very limited in-depth data and analysis available on state-of-the-art batteries for automotive applications," stated the study's lead author, Jonas Gorsch, a researcher at RWTH Aachen University in Germany's Production Engineering of E-Mobility Components. 

In order to solve this, the researchers examined the internal workings of the BYD Blade cell and the Tesla 4680 cell, concentrating on the unique performance characteristics and design of each battery. They evaluated the electrical and thermal performance of the cells, their mechanical designs and dimensions, and the precise material compositions of their electrodes. They also calculated the expenses of the materials used to produce the cells and the procedures used to assemble them. 


Engineers took apart batteries from Tesla and China's leading EV manufacturer to see what's inside
Courtesy of SynEvol 
Credit: Jonas Gorsch


"We were surprised to find no silicon content in the anodes of either cell, especially  in Tesla's cell, as silicon is widely regarded in research as a key material for increasing energy density." Gorsch stated. 

The engineers discovered that there were notable variations between the two battery types in terms of how quickly a battery charges for drains in relation to its maximum capacity. 

Additionally, by employing an electrode stack with a unique manufacturing step to laminate the edges of the separator that sits between the anode and the cathode, the researchers found that the BYD Blade uses a distinct technique to hold the electrode sheets in place. In contrast to the majority of manufacturers in the industry, the Tesla battery also includes a new binder, which is a polymer that keeps together the active components in the electrodes. 

Unexpected parallels between the batteries were also revealed: both employ laser welding, as opposed to ultrasonic welding, which is the method employed by many others in the industry, to join their thin electrode foils.  Additionally, the percentage of passive cell components, including as current collectors, housing, and busbars, is comparable even though the BYD cell is somewhat larger than the Tesla cell. 


Engineers took apart batteries from Tesla and China's leading EV manufacturer to see what's inside

Courtesy of SynEvol 
Credit: Jonas Gorsch



According to Gorsch, the study's findings show how two "highly innovative' but "fundamentally different " design techniques are used in the batteries made by BYD (the BYD Blade cell) and Tesla (the Tesla 4680 cell). He stated that more research is required to ascertain how mechanical cell design decisions affect the lifespans of the Tesla and BYD cells as well as the electrode performances in EV batteries. 

Gorsch stated that the data can assist battery-cell developers in making well-informed decisions regarding format, size, and active materials. "the findings provide both research and industry with benchmark for large-format cell designs, serving as a baseline for further cell analysis and optimization, " they added. 

 


Researchers Have Just Found a Secret Superpower in Microscopes
Posted by Okachinepa on 03/07/2025 @ 
SynEVOL Source
Physical Foundations of New Generative AI Based Quantitative Phase Imaging Method
Courtesy of SynEvol
Credit: Blaurock/CASUS



Labeling samples with dyes is a common technique in traditional microscopy, although it is expensive and time-consuming. Researchers have created a computational quantitative phase imaging (QPI) technique that uses the generative AI and chromatic aberration to get around these restrictions. 

Utilizing the inherent the differences in focus distances across various wavelengths, the method creates through focus image stacks from a single exposure.  This method makes it possible to image biological specimens, including actual clinical samples like red blood cells, with excellent quality by using a diffusion model that has been specially trained.  By offering a practical and effective substitute for traditional imaging methods, the discovery has the potential to completely transform diagnostics. 


Although labeling biological samples with dyes or other substances yields insightful information, there are serious limitations to this approach that restrict its application in clinical diagnosis. Time, costly equipment, and expensive reagents are all necessary. Consequently, label-free microscopy methods like as quantitative phase imaging (QPI) have been the focus of recent studies.

In contrast to conventional imaging techniques, QPI examines how a sample alters the phase of light traveling through it in addition to the light that is absorbed or scattered by it. The thickness, refractive index, and other structural characteristics of the sample are closely related to this phase shift. Computational QPI provides a more affordable option, even though QPI usually calls for expensive equipment.

Solving the Transport-of-Intensity Equation (TIE) is the foundation of one of the most popular computational QPI methods. This mathematical method uses recorded phase changes to rebuild a picture of the sample. It creates excellent images and is comparatively simple to include into current optical microscopes.

To remove artifacts, the TIE method frequently necessitates taking many pictures at various focus distances, which is a significant disadvantage. For many clinical applications, TIE-based QPI is not feasible due to the time-consuming and technically difficult nature of collecting these through-focus stacks.

According to Prof. Artur Yakimovich, Leader of a CASUS Young Investigator Group and corresponding author of the work presented at the AAAI Conference, "Our approach relies on the same principles as TIE but only needs one image because of a clever combination of physics and generative AI." Additional exposures with different focus distances do not provide information regarding the phase shift caused by the biological material.

Additionally, chromatic aberration allows for the creation of a through-focus stack from a single exposure. Only extremely specialized lenses may overcome the limitation of most microscope lens systems, which cannot completely bring all wavelengths of (polychromatic) white light to a single converging point. This indicates that, for example, the focus distances of red, green, and blue (RGB) light vary slightly.

According to Yakimovich, "one can construct a through-focus stack that facilitates computational QPI by recording the phase shifts of those three wavelengths separately using a conventional RGB detector, turning the handicap into an asset."

The distance between the red and blue light foci is extremely narrow, which presents a hurdle when using chromatic aberrations to achieve QPI, according to Gabriel Della Maggiora, a PhD candidate at CASUS and one of the paper's two lead authors. The conventional method of solving the TIE simply does not produce useful results.

After that, we decided to employ artificial intelligence. This thought ended up being essential, Della Maggiora continues. "Using only the very limited data input from the recording, a generative AI model was able to recover phase information after being trained on an open-access data set of 1.2 million images."

The Conditional Variational Diffusion Model (CVDM), a generative AI model for improving image quality that was introduced last spring, served as inspiration for the team. It is a member of the diffusion model family of generative AI models. The creators stress that while the outcomes are the same or better, training a CVDM requires a lot less computing power than training other diffusion models.

Della Maggiora and associates created a novel diffusion model that works with quantitative data by utilizing a CVDM method. They were ultimately able to achieve chromatic aberration-based computational QPI with this model.

They used, for instance, a standard brightfield microscope with a commercially available color camera to create microscopic images from actual clinical specimens in order to test their generative AI-based method: In contrast to another well-known computational TIE-based method, the method was able to reveal the donut-like form of red blood cells in a human urine sample.

The virtual lack of cloud artifacts in the images computed using the novel generative AI-based quantitative phase imaging version was an additional benefit.

The "Machine Learning for Infection and Disease" department at Yakimovich creates innovative computational methods for microscopy that may be used right away in clinical settings. For instance, the potential in diagnostics is enormous. Generative AI is one of the methods that are employed. The group's primary goal is to lessen hallucinations, which are a common side effect of generative AI. The important strategy here is to include physics-based components. This method is highly promising, as demonstrated by the case of AI-based quantitative phase imaging.

 


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